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041640 Rabbit Anti-SFTPB, ID (SFTPB, SFTP3, Pulmonary surfactant-associated protein B, 18kD pulmonary-surfactant protein, 6kD protein, Pulmonary surfactant-associated proteolipid SPL(Phe))

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P07988
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000533.3; NP_942140.2
Gene ID
6439
Gene #
SFTPB
Shipping Temp
Blue Ice
Storage Temp
-20°C
SFTPB, SFTP3, Pulmonary surfactant-associated protein B, 18kD pulmonary-surfactant protein, 6kD protein, Pulmonary surfactant-associated proteolipid SPL(Phe)

SFTPB is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 128-158 in the central region of human SFTPB, UniProt Accession #P07988
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SFTPB.
References
Baekvad-Hansen, M., et al. Eur. Respir. J. (2010) In press : Kim, W.J., et al. Eur. Respir. J. (2010) In press : Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) Cho, M.H., et al. Respir. Res. 11, 30 (2010) : Chaiworapongsa, T., et al. J. Matern. Fetal. Neonatal. Med. 21(9):663-670(2008)
USBio References
No references available
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