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041641 Rabbit Anti-SFTPC, CT (SFTPC, SFTP2, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P11686
Isotype
IgG
Grade
Affinity Purified
Applications
E IF IHC WB
Crossreactivity
Hu
Accession #
NP_001165828.1; P11686
Gene ID
6440
Gene #
SFTPC
Shipping Temp
Blue Ice
Storage Temp
-20°C
SFTPC, SFTP2, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Immunofluorescence : 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 144-173 in the C-terminal region of human SFTPC, UniProt Accession #NP_001165828.1; P11686.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human SFTPC.
References
1. Wambach, J.A., et al. Pediatr. Res. 68(3):216-220(2010) 2. Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) 3. Thouvenin, G., et al. Arch. Dis. Child. 95(6):449-454(2010) 4. Crossno, P.F., et al. Chest 137(4):969-973(2010) 5. Davila, S., et al. Genes Immun. 11(3):232-238(2010)
USBio References
No references available
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