SMPD1, CT

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Swiss Prot

P17405

Isotype

IgG

Grade

Affinity Purified

Applications

E FC IHC WB

Crossreactivity

Accession #

NP_000534.3

Gene ID

6609

Gene #

SMPD1

Shipping Temp

Blue Ice

Storage Temp

-20°C

SMPD1, ASM, Sphingomyelin phosphodiesterase, Acid sphingomyelinase

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].

Applications

Suitable for use in ELISA, Western Blot, Immunohistochemistry and Indirect Flow Cytometry. Other applications have not been tested.

Recommended Dilutions

Western Blot: 1:4000 Immunohistochemistry (FFPE): 1:500 Requires HIER using EDTA, pH 8.0 buffer pH 9.0 prior to staining. Indirect Flow Cytometry: 1:25 Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 391-419 in the C-terminal region of human SMPD1. Species Sequence Homology: bovine.

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity

Purified by Protein A and peptide affinity chromatography.

Specificity

Recognizes human SMPD1.

References

1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010). 3. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). 4. Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). 5. Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)

USBio References

No references available

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042054 Rabbit Anti-SMPD1, CT (SMPD1, ASM, Sphingomyelin phosphodiesterase, Acid sphingomyelinase)

Clone Type

Host

Source

Swiss Prot

Isotype

Grade

Applications

Crossreactivity

Accession #

Gene ID

Gene #

Shipping Temp

Storage Temp

SMPD1, ASM, Sphingomyelin phosphodiesterase, Acid sphingomyelinase

References

USBio References

Conjugates

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