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042056 Rabbit Anti-SMPD3, NT (SMPD3, Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase 2, Neutral sphingomyelinase II)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NY59
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_061137.1
Gene ID
55512
Gene #
SMPD3
Shipping Temp
Blue Ice
Storage Temp
-20°C
SMPD3, Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase 2, Neutral sphingomyelinase II

SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
SMPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the N-terminal region of human SMPD3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Filosto, S., et al. J. Biol. Chem. 285(14):10213-10222(2010)|Maupas-Schwalm, F., et al. Cell. Signal. 21(12):1925-1934(2009)|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Ito, H., et al. Biochim. Biophys. Acta 1789 (11-12), 681-690 (2009) :
USBio References
No references available
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