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You are here:Home » Antibodies » Abs to Toll Like Receptors (TLR) » Anti -TLR4, ID (TLR4, Toll-like receptor 4, hToll, CD284)

Anti -TLR4, ID (TLR4, Toll-like receptor 4, hToll, CD284)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B FC
TLR4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.
Catalog #042879
ApplicationsSuitable for use in Western Blot, Flow Cytometry and ELISA. Other applications have not been tested.
Recommended DilutionWestern Blot: 1:1000
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenKLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 669-698 in the central region of human TLR4, UniProt Accession #O00206.
Species sequence homologyBovine, hamster, porcine
SpecificityRecognizes human TLR4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTLR4, Toll-like receptor 4, hToll, CD284


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