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042899 Rabbit Anti-TM4SF1, NT (TM4SF1, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P30408
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo
Accession #
NP_055035.1
Gene ID
4071
Gene #
TM4SF1
Shipping Temp
Blue Ice
Storage Temp
-20°C
TM4SF1, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry (paraffin): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa16-45 in the N-terminal region of human TM4SF1, UniProt Accession #P30408; NP_055035.1
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TM4SF1. Species Crossreactivity: mouse
References
1. Gordon, G.J., et al. J. Natl. Cancer Inst. 101(9):678-686(2009) 2. Lekishvili, T., et al. J. Cell. Sci. 121 (PT 5), 685-694 (2008) : 3. Stelzl, U., et al. Cell 122(6):957-968(2005) 4. Chang, Y.W., et al. Int. J. Cancer 116(2):243-252(2005) 5. Kao, Y.R., et al. Clin. Cancer Res. 9(7):2807-2816(2003)
USBio References
No references available
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