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You are here:Home » Antibodies » Abs to Topoisomerases » Anti -TOP3B, CT (TOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1)

Anti -TOP3B, CT (TOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
Catalog #043130
ApplicationsSuitable for use in Western Blot, ELISA
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-500
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenTOP3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 825-854 amino acids from the C-terminal region of human TOP3B.
SpecificityHuman, mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1


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