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043268 Rabbit Anti-TRIP10, NT (TRIP10, CIP4, STOT, STP, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q15642
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_004231.1
Gene ID
9322
Gene #
TRIP10
Shipping Temp
Blue Ice
Storage Temp
-20°C
TRIP10, CIP4, STOT, STP, Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, Thyroid receptor-interacting protein 10

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
TRIP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-145 amino acids from the N-terminal region of human TRIP10.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human
References
Roignot, J., et al. Cancer Lett. 288(1):116-123(2010)|Hu, J., et al. Cell. Signal. 21(11):1686-1697(2009)|Banerjee, P.P., et al. J. Exp. Med. 204(10):2305-2320(2007)|Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)|Shimada, A., et al. Cell 129(4):761-772(2007)
USBio References
No references available
Conjugates
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