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043578 Rabbit Anti-UGT1A1, NT (UGT1A1, GNT1, UGT1, UDP-glucuronosyltransferase 1-1, Bilirubin-specific UDPGT isozyme 1, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1A1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P22309
Isotype
IgG
Grade
Affinity Purified
Applications
E IF IHC WB
Crossreactivity
Hu
Accession #
NP_000454.1
Gene ID
54658
Gene #
UGT1A1
Shipping Temp
Blue Ice
Storage Temp
-20°C
UGT1A1, GNT1, UGT1, UDP-glucuronosyltransferase 1-1, Bilirubin-specific UDPGT isozyme 1, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1A1

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunofluorescence: 1:10-1:50 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 65-90 in the N-terminal region of human UGT1A1
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A and peptide affinity chromatography
Specificity
Recognizes human UGT1A1
References
1.Italia, K.Y., et al. Clin. Biochem. 43 (16-17), 1329-1332 (2010). 2. Justenhoven, C., et al. Breast Cancer Res. Treat. 124(1):289-292(2010). 3. Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). 4. Sai, K., et al. Br J Clin Pharmacol 70(2):222-233(2010). 5. Kilic, I., et al. Int J Clin Pharmacol Ther 48(8):504-508(2010)
USBio References
No references available
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