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044409 Rabbit Anti-ZRANB1, CT (ZRANB1, TRABID, Ubiquitin thioesterase ZRANB1, TRAF-binding domain-containing protein, Zinc finger Ran-binding domain-containing protein 1)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9UGI0
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo
Gene ID
54764
Gene #
ZRANB1
Shipping Temp
Blue Ice
Storage Temp
-20°C
ZRANB1, TRABID, Ubiquitin thioesterase ZRANB1, TRAF-binding domain-containing protein, Zinc finger Ran-binding domain-containing protein 1

ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.

Applications
Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:50-1:100 Optimal dilution to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa665-692 in the C-terminal region of human ZRANB1. Species Sequence Homology: bovine
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A and peptide affinity chromatography
Specificity
Recognizes human ZRANB1 at ~80kD. |Species Crossreactivity: mouse
References
1. Tran, H., et al. Genes Dev. 22(4):528-542(2008). 2. Evans, P.C., et al. Biochem. J. 357 (PT 3), 617-623 (2001)
USBio References
No references available
Conjugates
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