AMI-1 CAS 160994-87-6, 134-47-4

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044499 AMI-1 CAS: 160994-87-6, 134-47-4

Specifications

References

CAS Number

160994-87-6, 134-47-4

Grade

Highly Purified

Molecular Formula

C21H12N2O9S2Na4

Molecular Weight

592.4

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Arginine N-methyltransferase inhibitor-1

Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8uM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0uM).

Synonyms

Arginine N-methyltransferase inhibitor-1

CAS Number

160994-87-6 (xNa), 134-47-4 (free base)

Molecular Weight

592.4

Molecular Formula

C21H12N2O9S2Na4

Solubility

Water, 100% ethanol or DMSO.

Appearance

Supplied as a brown solid.

Purity

≥99% (NMR)

Storage and Stability

Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) |2. A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) |3. Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach: Y. Feng, et al.; BBRC 379, 567 (2009)