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You are here:Home » Molecular Biology » MB-Apoptosis » APRIL, soluble (H98), Recombinant, Human (ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:)

APRIL, soluble (H98), Recombinant, Human (ACRP30headless:APRIL, ACRP30headless:CD256,
ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:)

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Specifications

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
Catalog #044565
Biological ActivityStimulates B cell proliferation.
SequenceThe extracellular domain of human APRIL (aa 98-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Molecular Weight~34kD (SDS-PAGE)
SourceHuman, HEK 293 cells
Purity>95% (SDS-PAGE)
Concentration0.1mg/ml
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
SpecificityBinds to human and mouse BCMA and TACI. Does not bind to proteoglycans.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:


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