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You are here:Home » Growth Factors, Cytokines » Growth Factors-BAFF » BAFF-R:Fc, Recombinant, Human (TNFRSF 13C, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BlySR3, CD268, BAFF Receptor)

BAFF-R:Fc, Recombinant, Human (TNFRSF 13C, Tumor Necrosis Factor Receptor Superfamily
Member 13C, BR3, BlySR3, CD268, BAFF Receptor)

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Specifications

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation . Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren's syndrome , Rheumatoid Arthritis (RA) , Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) . BAFF is also increased levels in some lymphoid cancers.
Catalog #044588
Biological ActivityInhibits BAFF activity. Detection of membrane-bound human and mouse BAFF in combination with PAb to human IgG1.
SequenceThe extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Molecular Weight~40kD (SDS-PAGE)
SourceHuman, HEK 293 cells
Purity>95% (SDS-PAGE)
Concentration1mg/ml
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
SpecificityBinds to human and mouse BAFF.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTNFRSF 13C, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BlySR3, CD268, BAFF Receptor


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