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You are here:Home » Antibodies » Abs to Interferon » Anti -Cardif (CARD Adapter Inducing Interferon-beta, IPS-1, MAVS, Mitochondrial Antiviral Signaling Protein, VISA, Virus-induced Signaling Adapter, Interferon-beta Promoter Stimulator Protein 1)

Anti -Cardif (CARD Adapter Inducing Interferon-beta, IPS-1, MAVS, Mitochondrial Antiviral
Signaling Protein, VISA, Virus-induced Signaling Adapter, Interferon-beta Promoter
Stimulator Protein 1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IP IH IC
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
Catalog #044625
ApplicationsSuitable for use in Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone NoAdri-1
HostMouse
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Purity>95% (SDS-PAGE)
ImmunogenRecombinant human Cardif (aa 160-450).
SpecificityRecognizes human Cardif.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCARD Adapter Inducing Interferon-beta, IPS-1, MAVS, Mitochondrial Antiviral Signaling Protein, VISA, Virus-induced Signaling Adapter, Interferon-beta Promoter Stimulator Protein 1


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