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044647 CD137, Recombinant, Mouse,Fc (4-1BB, TNFRSF9) CAS:

Specifications
Grade
Highly Purified
Swiss Prot
P20334
Molecular Weight
50
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C
4-1BB, TNFRSF9

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

Sequence
The extracellular domain of mouse CD137 (aa1-185) is fused at the C-terminus to the Fc portion of human IgG1.
Molecular Weight
~50kD (SDS-PAGE)
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Concentration
~1mg/ml
Form
Supplied as a 0.2um filtered solution in PBS.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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