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You are here:Home » Molecular Biology » MB-CD Markers » CD137L, Soluble, Recombinant, Human (4-1BBL, TNFSF9)

CD137L, Soluble, Recombinant, Human (4-1BBL, TNFSF9)

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Specifications

The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
Catalog #044651
SequenceThe extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a FLAG®-tag.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHuman, HEK 293 cells
Purity95% (SDS-PAGE) Endotoxin: 1EU/ug protein (LAL)
FormSupplied as a lyophilized powder from PBS, pH 7.2.
SpecificityBinds to human CD137.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names4-1BBL, TNFSF9


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