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You are here:Home » Biochemicals » Biochem-Apoptosis » Cyclopamine (11-Deoxyjervine, 11-Deoxojervine, HSDB 3505)

Cyclopamine (11-Deoxyjervine, 11-Deoxojervine, HSDB 3505)


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Cell permeable steroidal alkaloid. Specific sonic hedgehog signaling (Shh) pathway inhibitor. Directly interacts/inhibits Smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts. Arrests cell cycle at G0/G1. Apoptosis inducer.
Catalog #044717
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
CAS Number4449-51-8
Molecular FormulaC27H41NO2
Molecular Weight411.6
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names11-Deoxyjervine, 11-Deoxojervine, HSDB 3505

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