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You are here:Home » Biochemicals » Biochem-Antibiotics » Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193, Ramihyphin A)

Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193,
Ramihyphin A)

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Specifications

Potent immunosuppressant (same as FK-506 and rapamycin).
Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation.
Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2).
Prevents rejection of transplanted organs.
Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis).
Antibacterial. Antifungal. Antiparasitic.
Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release.
NF-kappaB suppressor by induction of unfolded protein response (UPR).
Anti-cancer compound. Apoptosis and autophagy inducer.
Inhibits nitric oxide synthesis induced by interleukin-1alpha, lipopolysaccharides and TNF-alpha.
Catalog #044718
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 3 years after receipt when stored at -20°C.
CAS Number59865-13-3
Molecular FormulaC62H111N11O12
Molecular Weight1202.60
Purity>98%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAntibiotic S 7481F1, Ciclosporin A, CsA, Cyclosporine, NSC 290193, Ramihyphin A


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