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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -CYLD (Cylindromatosis Tumor Suppressor Protein)

Anti -CYLD (Cylindromatosis Tumor Suppressor Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IC
Cylindromas are benign adnexal skin tumors caused by germ line mutations in the CYLD gene. In most cases the second wild type allele is lost in tumor tissue suggesting that CYLD functions as tumor-suppressor. CYLD is a protein of 956 amino acids harboring a functional deubiquitinating domain at the C-terminal end. CYLD was shown to interact with TRAF2, NEMO and TRIP. Furthermore, CYLD is a negative regulator of NF-kappaB activation mediated by TNF family members and IL-1beta. Downregulation of NF-kappaB activity depends on the deubiquitinating activity of CYLD which removes lysine-63 linked ubiquitin chains from target proteins. These findings indicate that cylindromas arise through constitutive NF-kappaB activation leading to hyperproliferation and tumor growth. In summary, CYLD contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappaB activation. It is a negative regulator of the Wnt signaling, inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Through the regulation of microtubule dynamics, it contributes to the regulation of cell proliferation, cell polarization, cell migration and angiogenesis. It plays a role in the regulation of inflammation and the innate immune response via its effects on NF-kappaB activation. Defects in CYLD are the cause i) of familial cylindromatosis (FCYL), also known as Ancell-Spiegler cylindromas or turban tumor; ii) of multiple familial trichoepithelioma type 1 (MFT1), also known as epithelioma adenoides cysticum of Brooke (EAC) and iii) of Brooke-Spiegler syndrome (BRSS), all characterized by the presence of many skin tumors.
Catalog #044719
ApplicationsSuitable for use in Immunocytochemistry, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 1% BSA, 50% glycerol, 0.02% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 56-70 (G56HSRIPSAKGKKNQI70) of human CYLD.
SpecificityRecognizes human CYLD. Detects a band of ~120kD by Western blot.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCylindromatosis Tumor Suppressor Protein


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