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You are here:Home » Biochemicals » Biochem-Molecular Biology » Ds(+)-threo-Isocitric acid trisodium salt ((1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid, (2R,3S)-Isocitric acid . trisodium salt)

Ds(+)-threo-Isocitric acid trisodium salt ((1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic
acid, (2R,3S)-Isocitric acid . trisodium salt)


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Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.
Catalog #044766
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
CAS Number903507-52-8
Molecular FormulaC6H5O7 . 3Na
Molecular Weight189.1+69.0
Purity>98% (NMR)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names(1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid, (2R,3S)-Isocitric acid . trisodium salt

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