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You are here:Home » Biochemicals » Biochem-Apoptosis » Etoposide (VP-16-213, NSC 141540)

Etoposide (VP-16-213, NSC 141540)

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Specifications

Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines.
DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication.p53 activator.
Blocks the cell cycle between the end of the S phase and the early G2 phase.
Catalog #044777
Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcription and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation.
Storage and StabilityShort-term Storage: +20°C
Long-term Storage: +20°C
Stable for at least 2 years after receipt when stored at +20°C. Store solutions in DMSO at 4°C. After reconstitution, prepare aliquots and store at -20°C.
CAS Number33419-42-0
Molecular FormulaC29H32O13
Molecular Weight588.6
Purity>98% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesVP-16-213, NSC 141540


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