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044789 RANKL, Soluble, Recombinant, Mouse, Fc (TRANCE, ODF, OPGL, TNFSF11, CD254) CAS:

Specifications
References
Grade
Highly Purified
Swiss Prot
O35235
Molecular Weight
55
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
TRANCE, ODF, OPGL, TNFSF11, CD254

RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.

Biological Activity
Induces osteoclastogenesis of bone marrow-derived macrophages.
Sequence
Mouse RANKL (aa 157-316) is fused to at the N-terminus to the Fc portion of human IgG1.
Specifcity
Binds to mouse RANK.
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Concentration
~0.1mg/ml (after reconstitution)
Form
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Product Reference: |●RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies.: A. Leibbrandt & J.M. Penninger; Adv. Exp. Med. Biol. 649, 100 (2009)|●
USBio References
No references available
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