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You are here:Home » Growth Factors, Cytokines » Growth Factors-FGF » FGF-23:Fc, Recombinant, Human (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor)

FGF-23:Fc, Recombinant, Human (Fibroblast Growth Factor 23, Tumor-derived
Hypophosphatemia-inducing Factor)

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Specifications

FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Catalog #044812
Biological ActivityActivates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
SequenceSignal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1.
Molecular Weight~60kD (SDS-PAGE, full-length) FGF23 is cleaved between arg179 and ser 180 (~40kD).
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Molecular Weight~60kD (SDS-PAGE, full-length)
SourceHuman, HEK 293 cells
Purity>90% (SDS-PAGE)
Concentration1mg/ml
FormSupplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesFibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor


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