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You are here:Home » Molecular Biology » Growth Factors-TNF » GITRL, Recombinant, Human (His) (Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18)

GITRL, Recombinant, Human (His) (Glucocorticoid-induced TNF Receptor Ligand, AITRL,
Activation-inducible TNF-related Ligand, TNFSF18)

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Specifications

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Catalog #044854
SequenceThe extracellular domain of human GITRL (aa 50-177) is fused at the N-terminus to a His-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Molecular Weight~16kD (SDS-PAGE)
SourceHuman, E. coli
Purity>90% (SDS-PAGE)
Concentration0.5mg/ml
Form0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2 150 mM NaCl.
SpecificityBinds to human GITR.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGlucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18


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