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You are here:Home » Antibodies » Abs to Infectious Disease Hepatitis » Anti -HCV, NS5B (Nonstructural Protein 5B)

Anti -HCV, NS5B (Nonstructural Protein 5B)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Catalog #044882
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No5B-3B1
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol
PurityPurified
ImmunogenRecombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (genotype 1a).
SpecificityRecognizes HCV NS5B (epitope mapped to NS5B aa 372-382). Recognizes genotype 1a and also 1b (albeit with lower affinity). Does not recognize genotype 2a.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNonstructural Protein 5B


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