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You are here:Home » Biochemicals » Biochem-Inhibitors » IBMX (3-Isobutyl 1-methylxanthine, NSC 165960, SC2964, EINECS 249-259-3)

IBMX (3-Isobutyl 1-methylxanthine, NSC 165960, SC2964, EINECS 249-259-3)


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Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor. Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis. Enhances differentiation of 3T3-L1 cells. Non-selective adenosine receptor antagonist. Inhibits Ca2+ ion channels. Activates TNF-alpha. Adipogenic. Activates leukotriene synthesis. Reduces inflammation and innate immunity.
Catalog #044890
IC50 values are 13, 18, 19, 32 and 50uM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively
SolubilityDMSO, Dichloromethane, Ether, Ethyl acetate, Methanol and ethanol. Insoluble in water.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number28822-58-4
Molecular FormulaC10H14N4O2
Molecular Weight222.3
Purity99% (HPLC)
FormSupplied as a white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names3-Isobutyl 1-methylxanthine, NSC 165960, EINECS 249-259-3

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