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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL-1alpha (Interleukin-1alpha)

Anti -IL-1alpha (Interleukin-1alpha)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E B
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Catalog #044905
ApplicationsSuitable for use in ELISA, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone NoBamboo-1
HostMouse
SourceMouse
Concentration1mg/ml
FormSupplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Purity>95% (SDS-PAGE)
ImmunogenRecombinant mouse mature IL-1alpha.
SpecificityRecognizes mouse IL-1alpha.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-1alpha


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