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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL-33 (Interleukin-33, IL-1F11, NF-HEV)

Anti -IL-33 (Interleukin-33, IL-1F11, NF-HEV)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Catalog #044924
ApplicationsSuitable for use in ELISA, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration1mg/ml
FormSupplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant mouse IL-33.
SpecificityRecognizes mouse IL-33. Detects a band of ~18kD by Western blot. Does not cross-react with human IL-33.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-33, IL-1F11, NF-HEV


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