IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)
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| Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. | | | Catalog # | 044929 | | Biological Activity | Activates human ST2-dependent NF-kappaB pathway. | | Sequence | Human IL-33 (aa 112-270) is fused at the C-terminus to a His-tag. | | Storage and Stability | Short-term Storage: +4°C | | Long-term Storage: -20°C | | Working aliquots are stable for up to 3 months when stored at -20°C. | | Molecular Weight | ~18kD (SDS-PAGE) | | Source | Human, E. coli | | Purity | >90% (SDS-PAGE) | | Concentration | 1mg/ml | | Form | Supplied as a liquid from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl. | | Specificity | Binds to human ST2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Interleukin-33, IL-1F11, NF-HEV |
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