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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)

IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)

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Specifications

Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Catalog #044929
Biological ActivityActivates human ST2-dependent NF-kappaB pathway.
SequenceHuman IL-33 (aa 112-270) is fused at the C-terminus to a His-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Molecular Weight~18kD (SDS-PAGE)
SourceHuman, E. coli
Purity>90% (SDS-PAGE)
Concentration1mg/ml
FormSupplied as a liquid from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl.
SpecificityBinds to human ST2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-33, IL-1F11, NF-HEV


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