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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)

IL-33, Recombinant, Human (His) (Interleukin-33, IL-1F11, NF-HEV)


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Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Catalog #044929
Recombinant protein corresponding to aa112-270, fused at the C-Terminus with a His-Tag
Biological ActivityActivates human ST2-dependent NF-kB pathway.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~18kD (SDS-PAGE)
SourceE. coli
Purity~90% (SDS-PAGE). Endotoxin: 1EU/ug (LAL)
FormSupplied as a liquid in 55mM Tris-Cl, pH 8.2, 150mM sodium chloride.
SpecificityBinds to human ST2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-33, IL-1F11, NF-HEV

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