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You are here:Home » Molecular Biology » Growth Factors-Interleukin » IL-33, Recombinant, Mouse (Interleukin-33, IL-1F11, NF-HEV)

IL-33, Recombinant, Mouse (Interleukin-33, IL-1F11, NF-HEV)

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Specifications

Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Catalog #044933
Biological ActivityActivates ST2-dependent NF-kappaB pathway.
SequenceMouse IL-33 (aa 109-266) is untagged.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Molecular Weight~18kD
SourceMouse, E. coli
Purity>95% (SDS-PAGE)
Concentration0.1mg/ml
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
SpecificityBinds to mouse and human ST2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-33, IL-1F11, NF-HEV


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