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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » IL-36 beta, Recombinant, Mouse (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)

IL-36 beta, Recombinant, Mouse (Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8)


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IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Catalog #044936
Biological ActivityInduces secretion of IL-6 in BMDCs at a concentration of 10 - 100ng/ml.
SequenceIL-36beta (mouse) (aa 31-183) is untagged.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Molecular Weight~17kD
SourceMouse, E. coli
Purity>95% (SDS-PAGE)
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2, with 0.5% trehalose.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin-36beta, Interleukin-1 Family Member 8, IL-1F8

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