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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » IL-36 gamma, Recombinant, Mouse (Interleukingamma, Interleukin-1 Family Member 9, IL-1F9)

IL-36 gamma, Recombinant, Mouse (Interleukingamma, Interleukin-1 Family Member 9, IL-1F9)


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IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Catalog #044938
Biological ActivityInduces secretion of IL-6 in BMDCs.
SequenceIL-36gamma (mouse) (aa 13-164) is untagged.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~17kD
SourceE. coli
Purity~95% (SDS-PAGE). Endotoxin: 0.01EU/ug (LAL)
Concentration~0.1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 0.5% trehalose. Reconstitute with 100ul sterile ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukingamma, Interleukin-1 Family Member 9, IL-1F9

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