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044955 Ingenol-5,20-acetonide CAS: 77573-43-4

Specifications
References
CAS Number
77573-43-4
Grade
Highly Purified
Molecular Formula
C23H32O5
Molecular Weight
388.5
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C/-20°C

Intermediate and starting material for the synthesis and preparation of ingenol 3-ester derivatives. For use in chemical synthesis see references. Has improved shelf life compared to ingenol.

Source
Semi-synthetic
Synonyms
(9R,12S,12aR,12bR)-12,12a-dihydroxy-2,2,7,7,9,11-hexamethyl-6,6a,7a,8,9,12,12a,12b-octahydro-4H,7H-6,9a-methanocyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d][1,3]dioxin-13-one
CAS Number
77573-43-4
Molecular Weight
388.5
Molecular Formula
C23H32O5
Solubility
Methanol, DMSO or dichloromethane
Appearance
Supplied as a white solid.
Purity
≥95% (HPLC)
Storage and Stability
May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. The chemistry of ingenol. 1. Ingenol and some of its derivatives: J.H. Opferkuch, et al.; Z. Naturforsch. 36b, 878 (1981)|2. Synthesis of Modified Ingenol Esters: G. Appendino, et al.; Eur. J. Org. Chem. 1999, 3413 (1999)|3. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway: M. Blanco-Molina, et al.; Chem. Biol. 8, 767 (2001)|4. Synthesis of sapintoxin D and N-methylanthranilate-based fluorescent bioprobes: F. Mainieri, et al.; Nat. Prod. Commun. 2, 375 (2007)
USBio References
No references available
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