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You are here:Home » Biochemicals » Biochem-Inflammation » Kdo2-Lipid A ((3-Deoxy-D-manno-octulosonic acid)2-Lipid A)

Kdo2-Lipid A ((3-Deoxy-D-manno-octulosonic acid)2-Lipid A)


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Defined substructure of the Re mutant of lipopolysaccharide (LPS).
Strong activator (<10ng/ml) of toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Catalog #044977
Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant) [1] by a modification of the PCP extraction method [2,3], converted to the uniform sodium salt form [4] and dissolved in sterile pyrogen-free double distilled water.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular FormulaC110H198N2Na4O39P2
Molecular Weight2326.70
SourceE. coli
PurityAbsence of detectable protein or DNA contaminants with agonistic TLR activity.
FormSupplied as a sterile, ready-to-use liquid in pyrogen-free double distilled water.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names(3-Deoxy-D-manno-octulosonic acid)2-Lipid A

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