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You are here:Home » Biochemicals » Biochem-Inflammation » Kdo2-Lipid A ((3-Deoxy-D-manno-octulosonic acid)2-Lipid A)

Kdo2-Lipid A ((3-Deoxy-D-manno-octulosonic acid)2-Lipid A)


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Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy.
Catalog #044977
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: +4°C
Stable for at least 2 years after receipt when stored at +4°C.
Molecular FormulaC110H198N2Na4O39P2
Molecular Weight2326.70
PurityAbsence of detectable protein or DNA contaminants with agonistic TLR activity.
FormSterile, ready-to-use solution in pyrogen-free double distilled water.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names(3-Deoxy-D-manno-octulosonic acid)2-Lipid A

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