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You are here:Home » Biochemicals » Biochem-Apoptosis » Lovastatin (Mevilonin, MK-803, 6-alpha-Methylcompactin, BRN 3631989)

Lovastatin (Mevilonin, MK-803, 6-alpha-Methylcompactin, BRN 3631989)

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Specifications

Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).
Catalog #045022
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number75330-75-5
Molecular FormulaC24H36O5
Molecular Weight404.6
Purity>98% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMevilonin, MK-803, 6-alpha-Methylcompactin, BRN 3631989


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