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You are here:Home » Molecular Biology » MB-Obesity Proteins » Nampt, Recombinant, Human (His) (Visfatin/PBEF, PBEF1, Pre-B Cell Colony Enhancing Factor 1, Nicotinamide Phosphoribosyltransferase)

Nampt, Recombinant, Human (His) (Visfatin/PBEF, PBEF1, Pre-B Cell Colony Enhancing Factor
1, Nicotinamide Phosphoribosyltransferase)

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Specifications

Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kD adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
Catalog #045067
Recombinant protein corresponding to aa1-491from Intracellular human Nampt fused at the C-terminus to a His-tag.
Biological ActivityShows adipogenic effects in stimulated differentiating 3T3-L1 cells.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.e made in assay buffer..
Molecular Weight~52kD (SDS-PAGE)
SourceE. coli
Purity~90% (SDS-PAGE). Endotoxin: 1EU/ug )LAL)
FormSupplied as a salt-free lyophilized powder. Reconstitute with ddH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPre-B Cell Colony Enhancing Factor 1, PBEF1, Nicotinamide Phosphoribosyltransferase


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