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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein)

Anti -NLRP3/NALP3 (NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold
Autoinflammatory Syndrome 1 Protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin-1beta (IL-1b) and IL-18. Members of the Nod-like receptor family, including NLRP3 / NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Catalog #045087
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone NoCryo-1
HostMouse
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).
SpecificityRecognizes mouse NLRP3/NALP3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein


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