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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NLRP6/NALP6 (NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6)

Anti -NLRP6/NALP6 (NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor
Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor,
PYRIN-containing APAF1-like Protein 5, NALP6)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
Catalog #045089
ApplicationsSuitable for use in Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone NoClint-1
HostMouse
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.
Purity>95% (SDS-PAGE)
ImmunogenRecombinant human NLRP6 (NACHT domain).
SpecificityRecognizes human NLRP6.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesNACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6


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