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045108 NU6102 (O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine) CAS: 444722-95-6

Specifications
References
CAS Number
444722-95-6
Grade
Highly Purified
Molecular Formula
C18H22N6O3S
Molecular Weight
402.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine

Potent CDK1/cyclin B (IC50 = 9.5nM) and CDK2/cyclin A3 (IC50 = 5.4nM) inhibitor. 1,000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6uM), DYRK1A (IC50 = 0.9uM), PDK1 (IC50 = 0.8uM) and ROCKII (IC50 = 0.6uM). Inhibits cell growth.

Alternate Name
O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine
CAS Number
444722-95-6
Molecular Formula
C18H22N6O3S
Molecular Weight
402.5
Purity
≥98% (NMR)
Appearance
White to off-white solid.
Solubility
DMSO
Method for Determining Identity
Proton NMR
Storage and Stability
Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
≥98% (NMR)
Form
Supplied as a white to off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Product Reference: |●Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor: T.G. Davies, et al.; Nat. Struct. Biol. 9, 745 (2002) |●N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2: I.R. Hardcastle, et al.; J. Med. Chem.47, 3710 (2004) |●Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2: K.L. Sayle, et al.; Bioorg. Med. Chem. Lett. 13, 3079 (2003)
USBio References
No references available
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