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You are here:Home » Biochemicals » Biochem-Apoptosis » Orlistat (Tetrahydrolipstatin, Xenical, Alli, Ro-18-0647)

Orlistat (Tetrahydrolipstatin, Xenical, Alli, Ro-18-0647)


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Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor. Anti-obesity and antihypercholesterolemic compound. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN). Anti-proliferative. Causes cell cycle arrest at G1 phase. Apoptosis inducer through caspase-3 activation. Sn-1-selective-diacylglycerol lipases alpha (DAGLalpha) inhibitor. Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways.
Catalog #045122
SolubilityDMSO, Ethanol, DMF
Method for Determining IdentityHPLC and IR
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number96829-58-2
Molecular FormulaC29H53NO5
Molecular Weight495.7
Purity>98% (HPLC)
FormWhite to off-white solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesTetrahydrolipstatin, Xenical, Alli, Ro-18-0647

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