You are here:Home
»
Biochemicals
»
Biochem-Cancer
»
Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate)
Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. | | | Catalog # | 045147 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light. | | CAS Number | 16561-29-8 | | Molecular Formula | C36H56O8 | | Molecular Weight | 616.80 | | Source | Semisynthetic | | Purity | ~95% (HPLC) | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate |
External Links
|
