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You are here:Home » Antibodies » Abs to Tubulin » Anti -Polyglutamylation Modification (Biotin) (Polyglutamylated Tubulin, Glutamylated Tubulin, Postranslational Protein Glutamylation)

Anti -Polyglutamylation Modification (Biotin) (Polyglutamylated Tubulin, Glutamylated
Tubulin, Postranslational Protein Glutamylation)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IP IC
Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved from and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and involved in cell cycle and cell proliferation.
Catalog #045160
ApplicationsSuitable for use in Immunocytochemistry, Immunoprecipitation, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone NoGT335
HostMouse
Concentration1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
Purity>95% (SDS-PAGE)
ImmunogenOctapeptide EGEGE*EEG, modified by the addition of two glutamyl units onto the fifth E (indicated by an asterisk).
SpecificityRecognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated alpha- and beta-tubulin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPolyglutamylated Tubulin, Glutamylated Tubulin, Postranslational Protein Glutamylation


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