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You are here:Home » Biochemicals » Biochem-Antibiotics » Puromycin 2HCl (CL16,536, NSC 3055, Stylomycin)

Puromycin 2HCl (CL16,536, NSC 3055, Stylomycin)


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Aminonucleoside antibiotic.
Protein synthesis inhibitor. Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation. Translational inhibitor in prokaryotic and eukaryotic cells in both in vitro and in vivo systems.
Inhibits the transport of proteins into the mitochondria in vitro.
Reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase (metallopeptidase).
Apoptosis inducer.
Inhibits the growth of Gram-positive bacteria, various animal and insect cells. Fungi and Gram-negative bacteria are resistant due to the low permeability to the antibiotic.
Antineoplastic agent.
Used in cell biology as selective agent in cell culture systems. It allows selection for cells that contain the resistance gene puromycin N-acetyl-transferase (PAC). Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg/ml, while cells in suspension are sensitive to concentrations as low as 0.5 to 2 µg/ml. Puromycin-resistant stable mammalian cell lines can be generated in less than one week.
Catalog #045182
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number58-58-2
Molecular FormulaC22H29N7O5 . 2HCl
Molecular Weight471.5+73.0
Purity>98% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCL16,536, NSC 3055, Stylomycin

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