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You are here:Home » Biochemicals » Biochem-Cancer » (R)-Roscovitine (6-Benzylamino-2-(R)-9-isopropylpurine)

(R)-Roscovitine (6-Benzylamino-2-(R)-9-isopropylpurine)

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Specifications

Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.
Catalog #045188
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number186692-46-6
Molecular FormulaC19H26N6O
Molecular Weight354.5
Purity>98% (NMR)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names6-Benzylamino-2-(R)--9-isopropylpurine


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