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You are here:Home » Biochemicals » Biochem-Antibiotics » Radicicol (Monorden, NSC 294404, RHI-12648)

Radicicol (Monorden, NSC 294404, RHI-12648)


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Antibiotic. Protein tyrosine kinase inhibitor. Has antifungal, antimalarial, antiangiogenic (in vivo), anti-inflammatory and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages. Potent HSP90 inhibitor. Anticancer compound. In vivo Rad/Raf interaction inhibitor. Inhibitor of AP-1-, NF-kappaB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II). Non-competitive inhibitor of ATP citrate lyase. DNA topoisomerase VI and type II DNA topoisomerase inhibitor. Protects against LPS/IFN-gamma-induced neuronal cell death. Apoptosis inducer.
Catalog #045192
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
CAS Number12772-57-5
Molecular FormulaC18H17ClO6
Molecular Weight364.8
Purity>99% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMonorden, NSC 294404, RHI-12648

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