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You are here:Home » Antibodies » Abs to DEAD Box Proteins » Anti -RIG-I (Biotin) (RIG-1, Retinoic Acid-inducible Gene 1 Protein, DEAD-box Protein 58, Probable ATP-dependent RNA Helicase DDX58)

Anti -RIG-I (Biotin) (RIG-1, Retinoic Acid-inducible Gene 1 Protein, DEAD-box Protein 58,
Probable ATP-dependent RNA Helicase DDX58)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IP IH
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
Catalog #045256
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation, Western Blot
Recommended DilutionOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoAlme-1
HostMouse
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
Purity>95% (SDS-PAGE)
ImmunogenRecombinant human RIG-I (aa 201-713).
SpecificityRecognizes human and mouse RIG-I.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRIG-1, Retinoic Acid-inducible Gene 1 Protein, DEAD-box Protein 58, Probable ATP-dependent RNA Helicase DDX58


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