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You are here:Home » Biochemicals » Biochem-Inflammation » Salsalate (Salicylsalicylic acid, NSC 49171, BRN 2590908, 2-Hydroxy-2-carboxyphenyl ester-benzoic acid)

Salsalate (Salicylsalicylic acid, NSC 49171, BRN 2590908, 2-Hydroxy-2-carboxyphenyl
ester-benzoic acid)


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Nonacetylated salicylate. Non-steroidal anti-inflammatory drug (NSAID). Reduces pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis and related rheumatic conditions. Prostaglandin synthesis inhibitor in vivo. Inactivates cyclooxygenase-1 (COX-1) and -2 (COX-2). IKKbeta/NF-kappaB inhibitor (at significantly higher concentrations than required for COX inhibition). Used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain.
Catalog #045269
Salsalate reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes. Reduces blood glucose, triglyceride, free fatty acid and C-reactive protein concentrations, improves glucose utilization and increases circulating insulin and adiponectin concentrations in obese adults at risk for the development of type 2 diabetes as well as for patients with type 2 diabetes. Dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.
Solubility Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number552-94-3
Molecular FormulaC14H10O5
Molecular Weight258.2
FormWhite to off-white powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSalicylsalicylic acid, NSC 49171, BRN 2590908, 2-Hydroxy-2-carboxyphenyl ester-benzoic acid

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