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You are here:Home » Biochemicals » Biochem-Apoptosis » Simvastatin (MK-733, Synvinolin, BRN 4768037)

Simvastatin (MK-733, Synvinolin, BRN 4768037)


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Synthetic analog of Lovastatin. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Smooth muscle cell proliferation inhibitor. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Proteasome modulator. Stimulates bone formation. Apoptosis inducer. Anticancer compound. Increases cellular resistance to anticancer agents such as doxorubicin and etoposides. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation.
Catalog #045282
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Stable for at least 2 years after receipt when stored at -20°C.
CAS Number79902-63-9
Molecular FormulaC25H38O5
Molecular Weight418.6
Purity>98% (HPLC)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMK-733, Synvinolin, BRN 4768037

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