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You are here:Home » Molecular Biology » MB-Sirtuins » Sirtuin 2, Recombinant, Human (His) (SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2)

Sirtuin 2, Recombinant, Human (His) (SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like
protein 2, SIR2L2)

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Specifications

Sirtuin 2 (SIRT2) is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin 2 achieves neuroprotection and identifies Sirtuin 2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.
Catalog #045294
Biological ActivityHDAC activity.
SequenceHuman sirtuin 2 (aa 2-389) is fused at the N-terminus to a His-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Molecular Weight~45kD (SDS-PAGE)
SourceHuman, E. coli
Purity>90% (SDS-PAGE)
Concentration0.4mg/ml
Form0.2um-filtered solution in 50mM TRIS-Cl, pH 8.2, 100mM NaCl.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2


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