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You are here:Home » Molecular Biology » MB-Sirtuins » Sirtuin 7, Recombinant, Human (His) (SIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like Protein 7, SIR2L7)

Sirtuin 7, Recombinant, Human (His) (SIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like
Protein 7, SIR2L7)

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Specifications

Sirtuin 7 (SIRT7) is a NAD-dependent protein deacetylase. It is required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. It promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. Sirtuin 7 is an essential regulator of tissue homeostasis in the heart. Sirt7-deficient animals undergo a reduction in mean and maximum lifespans and develop heart hypertrophy and inflammatory cardiomyopathy. Sirt7 interacts with p53 and efficiently deacetylates p53 in vitro, which corresponds to hyperacetylation of p53 in vivo and an increased rate of apoptosis in myocardium.
Catalog #045302
Biological ActivityHDAC activity.
SequenceHuman sirtuin 7 (aa 1-400) is fused at the N-terminus to a His-tag.
Storage and StabilityShort-term Storage: +4°C
Long-term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.
Molecular Weight~45kD (SDS-PAGE)
SourceHuman, E. coli
Purity>90% (SDS-PAGE)
Form0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl and 1mM DTT.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSIRT7, NAD-dependent Deacetylase Sirtuin-7, SIR2-like Protein 7, SIR2L7


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